![]() ![]() ![]() Since the DP subunit is an obligate partner for efficient DNA binding of E2F to canonical E2F response elements (TTT C/ G G/ CCGC) in growth-related target promoters, it is also essential for promotion of cell cycle progression 4, 5. Normal growth signals, such as serum stimulation of fibroblasts, induce phosphorylation of RB family proteins by cyclin-dependent kinases (CDKs), resulting in an increase in E2F transcriptional activity, activation of the growth-related target genes, and subsequent cell cycle progression 1, 2, 3. ![]() RB family proteins directly bind to and inactivate E2F in the resting state. E2F activity is regulated by retinoblastoma (RB) family proteins (pRB, p107 and p130) during the cell cycle. E2F family proteins (E2F1-E2F5) form heterodimeric complexes with DP family proteins (DP1 and DP2), generating E2F transcriptional activity that regulates expression of growth-related target genes 1, 2, 3. ![]()
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